Supplementary material 7 to: Focused review format prototype

Flemyng E, Mitchell D
https://doi.org/null

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Differences between the protocol and previous versions

Differences between the protocol and previous versions that have been carried forward in this update include:

Important note: For some studies, the number of treatment failures was only reported for those who started their study inhaler, or it was not clear how many participants were analysed and under what criteria treatment failures were counted. The only way to include these studies in the redefined primary analysis based on the full randomised population was to make assumptions about the data and use the reported number of treatment failures with the denominator for the full randomised population. This assumes that no participants who did not need their inhaler failed treatment and required oral steroids. The potential impact of making this assumption is dealt with explicitly in the review through the risk of bias assessment and reporting, and with sensitivity analyses using instead the number taking their study inhaler as the denominator.