Allowing for uncertainty due to missing outcome data in meta-analysis

Missing outcome data are commonly encountered in clinical trials and may compromise the validity of the estimated treatment effects. Meta-analysts typically assume that the missing data problem has been solved at the meta-analysis level and conduct an available case analysis. However, bias from missing outcome data is accumulated in a synthesis of those trials using meta-analysis. In this webinar, we present methods for estimating meta-analytic summary treatment effects when some outcome data are missing by using a statistical (pattern mixture) model to allow for uncertainty in the missing information. We quantify the degree of departure from the MAR assumption by introducing an informative parameter that relate the outcome in the missing data to that in the observed. This parameter is not informed by the data and we resort to expert opinion to inform or conduct a sensitivity analysis. We present a Stata command that applies the suggested methodology i) for both dichotomous and continuous outcomes ii) for pairwise and network meta-analysis. We illustrate the method using examples from mental health trials where outcome data are rarely missing at random (MAR).

This webinar is organised by the Cochrane Statistical Methods Group, with the support from Cochrane Membership, Learning and Support Services. The webinar will consist of a presentation, followed by a question and answers session.

Presenter bios:

Dimitris Mavridis, Department of Primary Education, University of Ioannina, Ioannina, Greece.

Anna Chaimani, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS-UMR1153), Inserm / Université Paris Descartes

Sign up

Monday, 18th June 2018 10:00 UTC [check the time in your time zone] SIGN UP HERE

You will need a Cochrane Account to sign up for this webinar. If you don’t have a Cochrane Account you will be able to register for **free** on the following page. You will be able to use this account for all future activity. A brief guidance on how to sign up using your Cochrane Account is available here and if you have any problems, please contact