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    Chapter 1: Starting a review

    Toby J Lasserson, James Thomas, Julian PT Higgins Key Points: Systematic reviews address a need for health decision makers to be able to access high quality, relevant, accessible and up-to-date information. Systematic reviews aim to minimize bias through ...
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    Chapter 2: Determining the scope of the review and the questions it will address

    James Thomas, Dylan Kneale, Joanne E McKenzie, Sue E Brennan, Soumyadeep Bhaumik Key Points: Systematic reviews should address answerable questions and fill important gaps in knowledge. Developing good review questions takes time, expertise and engagement ...
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    Chapter 3: Defining the criteria for including studies and how they will be grouped for the synthesis

    Joanne E McKenzie, Sue E Brennan, Rebecca E Ryan, Hilary J Thomson, Renea V Johnston, James Thomas Key Points: The scope of a review is defined by the types of population (participants), types of interventions (and comparisons), and the types of outcomes ...
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    Chapter 5: Collecting data

    Tianjing Li, Julian PT Higgins, Jonathan J Deeks Key Points: Systematic reviews have studies, rather than reports, as the unit of interest, and so multiple reports of the same study need to be identified and linked together before or after data extraction ...
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    Chapter 6: Choosing effect measures and computing estimates of effect

    Julian PT Higgins, Tianjing Li, Jonathan J Deeks Key Points: The types of outcome data that review authors are likely to encounter are dichotomous data, continuous data, ordinal data, count or rate data and time-to-event data. There are several different ...
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    Chapter 8: Assessing risk of bias in a randomized trial

    Julian PT Higgins, Jelena Savović, Matthew J Page, Roy G Elbers, Jonathan AC Sterne Key Points: This chapter details version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2), the recommended tool for use in Cochrane Reviews. RoB 2 is stru ...