Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy

We are pleased to announce a major update of the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy (version 2) for release in 2021/2022.

The Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy is the official guide that describes in detail the process of preparing and maintaining systematic reviews of test accuracy for Cochrane. The Handbook has been produced by the Cochrane Screening and Diagnostic Test Methods Group. It is a step-by-step guide for those conducting systematic reviews of test accuracy and a reference for more experienced authors.

The Handbook is applicable to all systematic reviews of test accuracy though is specifically relevant to Cochrane Reviews. Part 1 covers information specific to Cochrane Reviews of diagnostic test accuracy. Part 2 introduces test accuracy studies and discusses when it might be appropriate to conduct them. Part 3 covers the methods used in systematic reviews of test accuracy and how to present the findings, including collecting data, assessing risk of bias in the included studies, and undertaking meta-analysis. 


PDF versions of editorially accepted chapters are available to registered Cochrane contributors below, primarily for training purposes. These will be added below as and when they are ready. 

Contents
 

Part 1: About Cochrane Reviews of diagnostic test accuracy

  1. Introduction
  2. Planning a Cochrane Review of diagnostic test accuracy 

Part 2: Introducing test accuracy

  1. Evaluating diagnostic tests
  2. Understanding the designs of test accuracy studies
  3. Understanding test accuracy statistics

Part 3: Systematic review of test accuracy methods and presentation

  1. Defining the review question
  2. Searching for studies
  3. Assessing risk of bias and applicability
  4. Collecting data
  5. Understanding meta-analysis
  6. Undertaking meta-analysis
  7. Presenting findings
  8. Drawing conclusions
  9. Writing a plain language summary  

Important notes

  • A book version (first edition) of this Handbook, to be published by Wiley in 2022, will comprise chapters 1–14. The online (browsable) version will include chapters 1–14 with supplements.
  • These draft versions are provided to individual Cochrane members for personal use only, and an Archie login is required for access. These chapters are not for general distribution and all content remains the copyright of Cochrane.
  • These drafts will undergo further work. Further drafts may be posted here before finalization.
  • Please cite the material as set out at the beginning of each chapter, including the exact date of the version.
  • While we are not inviting a formal consultation, please email us (support@cochrane.org) if you identify major problems with the proposed Handbook guidance.

Core editorial team

Jon Deeks (Senior Scientific Editor)
Patrick Bossuyt (Senior Scientific Editor)
Mariska Leeflang (Associate Scientific Editor)
Yemisi Takwoingi (Associate Scientific Editor)
Ella Flemyng (Managing Editor)
Laura Mellor (Editorial Assistant)

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