Question formulation and protocol development for systematic reviews with network meta-analysis

These videos, orginially part of the NMA Learning Live Webinar series, are from a 'how to' webinar session covering the development of a ‘PICO’ question, assumptions & how they impact on analysis.

They are intended for people who are interested in undertaking a network meta-analysis, or who are actively developing a protocol for a review that intends to conduct this analysis type. In addition to review author teams, CRG editors and methodologists are also be able to learn about the importance of getting the question and methods right when planning an NMA.

The webinar was delivered in November 2019 and below you will find the videos from the webinar, together with accompanying slides to download [PDF].

Part 1: Introduction to NMA; rationale for NMA protocols

Part 2: NMA protocols: Rationale for the review, framing the research question, transitivity

Part 3: NMA protocols: Searching, selecting studies, extracting data; effect measures, statistical analysis, evaluating transitivity and coherence; reporting bias, confidence in evidence

Part 4: Conclusion, questions and answers


Presenter Bio

Anna Chaimani is a Senior Research Fellow at the Research Centre of Epidemiology and Statistics, Paris Descartes University. She is also a co-convenor of the Cochrane Statistical Methods Group and of the Cochrane Comparing Multiple Interventions Methods Group. She has worked on several topics in network meta-analysis such as small-study effects, software development, presentation and reporting of results, missing outcome data.


Part 1: Introduction to NMA; rationale for NMA protocols


Part 2: NMA protocols: Rationale for the review, framing the research question, transitivity


Part 3: NMA protocols: Searching, selecting studies, extracting data; effect measures, statistical analysis, evaluating transitivity and coherence; reporting bias, confidence in evidence


Part 4: Conclusion, questions and answers


Additional materials

Download the slides from the webinar [PDF]